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KMID : 0360419690050010065
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Korean Journal of Pharmacology
1969 Volume.5 No. 1 p.65 ~ p.72
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Potentiation by Tetrabenezine of Pressor Activity of Norepinephrine in Rabbits
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Abstract
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After administration of tetrabenazine (TBZ) 40 mg/kg), the pressor and cardioaccelerator responses of rabbits (whole anesthetized and spinal) to norepinephrine and tyramine were studied. The maxmal potentiation of the pressor activity of norepinephrine developed about 10 hours after TBZ administration. At this time the pressor response to tyramine was not decreased. The cardioaccelerator responses to both amines were not significantly altered. The TBZ-induced supersensitivity to norepinephrine was not increased by additional intravenous reserpine, but it was further increased by giving desipramine. Carbachol, given 2 and 6 hours after TBZ administration, inhibited the development of supersensitivity to norepinephrine by TBZ. The TBZ-induced supersensitivity was discussed in relation to reserpine-induced supersensitivity.
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